Реакция #322579

Уравнение реакции

1,3-dibromopropane

3-acetamidophenol

potassium carbonate

→

3-(3-acetamidophenoxy)propyl bromide

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ТемператураThe resulting mixture was heated
2. 2
   Температураat reflux for 6 hours
3. 3
   Другоеovernight
4. 4
   Другоеat room temperature
5. 5
   ФильтрацияSolids were filtered from the reaction mixture
6. 6
   Концентрированиеthe solution was concentrated to an oil, which
7. 7
   Другоеwas purified

Методика

To 3-acetamidophenol (15.1 g) in dichloromethane (500 ml, dry) was added potassium carbonate (20 g) and then 1,3-dibromopropane (30 g). The resulting mixture was heated at reflux for 6 hours and then overnight at room temperature. After an additional 24 hours, the reaction was complete. Solids were filtered from the reaction mixture, and the solution was concentrated to an oil, which was purified to yield 3-(3-acetamidophenoxy)propyl bromide, 13.2 g.

Источник