Реакция #3223

Уравнение реакции

methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate

trifluoroacetic acid

→

title compound

Выход 87.0%

Methyl 2-amino-4,6-dichloro-5-methoxybenzoate

Выход 87.0%

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   ПромывкаThe reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4)
2. 2
   Фильтрацияfiltered
3. 3
   Концентрированиеconcentrated

Методика

A solution o#methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate (2.3 g, 6.6 mM) and trifluoroacetic acid (6.0 g, 53 mM) in methylene chloride (23 mL) was stirred at room temperature for 1.5 hr. The reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4), filtered and concentrated to obtain (87%) the title compound as a yellow oil; MS(CI): 250 (M+H).

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