Реакция #321869

Уравнение реакции

dihydrochloride

3-(piperidin-1-yl)-propylamine

4,7-dichloroquinoline

hydrochloric acid

→

(7-Chloro-quinolin-4-yl)-(3-piperidin-1-yl-propyl)-amine

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Другоеrecrystallized from acetonitrile/ethanol
2. 2
   Другоеyielded colourless crystals, m.p.: 137°-141° C.

Методика

2.73 g from 2.83 g of 3-(piperidin-1-yl)-propylamine and 3.94 g of 4,7-dichloroquinoline (reaction duration, 16 hours at 140° C.); the base (yellowish crystals from acetonitrile, m.p.: 113°-116° C.) was converted with isopropanolic hydrochloric acid into the dihydrochloride which when recrystallized from acetonitrile/ethanol, yielded colourless crystals, m.p.: 137°-141° C.

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