Реакция #321868

Уравнение реакции

dihydrochloride

4,7-dichloroquinoline

3-(pyrrolidin-1-yl)-propylamine

hydrochloric acid

→

(7-Chloro-quinolin-4-yl)-(3-pyrrolidin-1-yl-propyl)-amine

Условия реакции

Обработка

1. 1
   Другоеrecrystallized from acetonitrile/ethanol
2. 2
   Другоеyielded colourless crystals, m.p.: 204°-206° C.

Методика

3.08 g from 7.72 g of 4,7-dichloroquinoline and 5 g of 3-(pyrrolidin-1-yl)-propylamine (reaction duration 16 hours at 140° C.); the base was converted with isopropanolic hydrochloric acid into the dihydrochloride which when recrystallized from acetonitrile/ethanol, yielded colourless crystals, m.p.: 204°-206° C.

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