Реакция #321866

Уравнение реакции

4,7-dichloroquinoline

2-methyl-2-(piperidin-1-yl)-propylamine

phenol

→

colourless crystals

Выход 31.6%

(7-Chloro-quinolin-4-yl)-(1,1-dimethyl-2-piperidin-1-yl-ethyl)-amine

Выход 31.6%

Условия реакции

Обработка

1. 1
   ДругоеThe crude reaction product
2. 2
   Другоеwas purified on 200 g of aluminium oxide (activity grade II)
3. 3
   Другоеto recrystallization
4. 4
   workup.ADDITIONa 1:1 mixture of toluene and acetone
5. 5
   Промывкаthe product was eluted
6. 6
   Другоеafter recrystallization from 5 ml of acetonitrile

Методика

4.57 g of 4,7-dichloroquinoline, 7.5 g of 2-methyl-2-(piperidin-1-yl)-propylamine and 0.75 g of phenol were reacted at 180° C. for 16 hours. The crude reaction product, isolated as in the preceeding Example, was purified on 200 g of aluminium oxide (activity grade II) prior to recrystallization; a 1:1 mixture of toluene and acetone was used as the eluent. After a fore-run, which contained unreacted 4,7-dichloroquinoline, the product was eluted and, after recrystallization from 5 ml of acetonitrile, yielded 0.8 g of colourless crystals, m.p.: 143°-147° C.

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