Реакция #3215

Уравнение реакции

6-iodo-1H-indole-2,3-dione

water

→

title compound

Выход 81.8%

7-Iodo-2H-3,1-benzoxazine-2,4(1H)-dione

Выход 81.8%

Растворители

acetic acid

acetic anhydride

Условия реакции

Обработка

1. 1
   Температураwhile maintaining the temperature of the reaction mixture at 80°-90° C
2. 2
   Температураcooled
3. 3
   ФильтрацияThe resulting mixture was filtered
4. 4
   Другоеthe collected solids dried

Методика

To a stirred warm (80° C.) solution of 6-iodo-1H-indole-2,3-dione (3.0 g, 11 mM) in acetic acid (10 mL) and acetic anhydride (10 mL) was added in small portions chromium trioxide (1.83 g, 18.3 mM) while maintaining the temperature of the reaction mixture at 80°-90° C. The reaction mixture was then heated at 80° C. for 10 min, cooled and poured into water. The resulting mixture was filtered and the collected solids dried to provide the title compound as a yellow solid (2.6 g, 81.8%); MS(CI): 290 (M+H).

Источник