Реакция #321471

Уравнение реакции

5-fluoroisatin

acetic anhydride

dimethylaminopyridine

→

5-fluoroisatin acetamide

isatin propionamide

Растворители

THF

Условия реакции

Обработка

1. 1
   ДругоеTHF is then removed
2. 2
   workup.ADDITIONdichloromethane is added
3. 3
   Другоеthe crystals are collected
4. 4
   Другоеdried

Методика

A mixture of 5-fluoroisatin (III, 0.803 g), acetic anhydride (0.546 g), dimethylaminopyridine (0.0059 g) and THF (25 ml) is stirred at 20°-25° for 1.25 hr. THF is then removed and dichloromethane is added. After standing, the crystals are collected and dried to give 5-fluoroisatin acetamide (IV).

Источник