Реакция #320613

Уравнение реакции

6-ethoxycarbonyl-7-hydroxy-thieno[3,2-b]pyridin-5(4H)-one

1,1-dimethylpropargylamine

→

6- [(1,1-Dimethylpropinyl-)aminocarbonyl-]-7-hydroxy-thieno[3,2-b]pyridin-5(4H)-one

Растворители

EtOH

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed under reduced pressure
2. 2
   ФильтрацияThe solid was filtered off
3. 3
   Другоеpurified chromatographically (silica gel, methylene chloride/methanol=8/1)

Методика

3.1 g (13 mmol) of 6-ethoxycarbonyl-7-hydroxy-thieno[3,2-b]pyridin-5(4H)-one and 1.3 g (1.2 eq.) of 1,1-dimethylpropargylamine in 80 ml of EtOH were stirred for 8 hours at 150° C. in an autoclave. The solvent was removed under reduced pressure and the solid residue was stirred with diethyl ether. The solid was filtered off and purified chromatographically (silica gel, methylene chloride/methanol=8/1).

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