Реакция #3205

Уравнение реакции

4,6-dimethyl-1H-indole-2,3-dione

water

→

title compound

Выход 31.0%

5,7-Dimethyl-2H-3,1-benzoxazine-2,4(1H)-dione

Выход 31.0%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураwhile maintaining the temperature of the reaction mixture at 65°-70° C
2. 2
   Температураcooled
3. 3
   Фильтрацияfiltered

Методика

To a stirred warm (60° C.) solution of 4,6-dimethyl-1H-indole-2,3-dione (2.0 g, 11.4 mM) in acetic acid (20 mL) was added in small portions chromium trioxide (6.6 g, 66 mM) while maintaining the temperature of the reaction mixture at 65°-70° C. The reaction mixture was then heated at 80° C. for one hour, cooled, poured into water (150 mL) and filtered to obtain the the title compound (0.67 g, 31%) as a light yellow solid; MS(CI): 192 (M+H).

Источник