Реакция #318559

Уравнение реакции

2,4,6-trichloronitrobenzene

2-(β-aminoethoxy)ethanol

→

4-chloro-2-(β-hydroxyethoxyethyl)amino6-(β-hydroxyethoxyethyl)aminonitrobenzene

Растворители

dioxan

Условия реакции

Обработка

1. 1
   Температураis heated
2. 2
   Температураto reflux of the dioxon
3. 3
   ДругоеThe product expected crystallizes
4. 4
   Промывкаwashing with water
5. 5
   Другоеdrying
6. 6
   Температураby heating under vacuum
7. 7
   Другоеthe product is recrystallized from acetonitrile

Методика

The mixture consisting of 0.1 mole (22.6 g) of 2,4,6-trichloronitrobenzene, 0.6 mole (63 g) of 2-(β-aminoethoxy)ethanol and 20 ml of dioxan is heated to reflux of the dioxon. After 4 hours, the reaction mixture is poured onto to 200 g of ice. The product expected crystallizes on acidifying with concentrated hydrochloric acid. After draining, washing with water and drying by heating under vacuum, the product is recrystallized from acetonitrile and then from toluene. It melts at 83° C.

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