Реакция #317290

Уравнение реакции

4,7-dichloroquinoline

1,2-diaminoethane

→

7-chloro-4-[N-(2-aminoethyl)amino]-quinoline

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter adding 1N soda (15 ml)
2. 2
   Другоеthe solid obtained
3. 3
   Экстракцияis extracted with ethyl acetate (100 ml) at 50° C
4. 4
   ПромывкаThe organic phase is washed with distilled water
5. 5
   Сушкаagain with distilled water and finally is dried on sodium sulphate
6. 6
   ДругоеThe solvent is evaporated
7. 7
   Другоеthe product obtained
8. 8
   Другоеis vacuum-dried (1.3 g, 58%)

Методика

A mixture of 4,7-dichloroquinoline (2.0 g, 10 mmol) and 1,2-diaminoethane (2.7 g, 45 mmol) is heated at 85° C. for 5 hours with magnetic stirring. After adding 1N soda (15 ml), the solid obtained is extracted with ethyl acetate (100 ml) at 50° C. The organic phase is washed with distilled water and then using a saturated NaCl solution and then again with distilled water and finally is dried on sodium sulphate. The solvent is evaporated and the product obtained is vacuum-dried (1.3 g, 58%).

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