Реакция #316939

Уравнение реакции

2-thiophencarboxylic acid hydrazide

benzyl isothiocyanate

→

N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide

Выход 89.3%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Другоеthe reaction vessel was removed from the heat source
2. 2
   ФильтрацияThe resulting crystals were collected by vacuum filtration
3. 3
   Промывкаwashed with diethyl ether
4. 4
   Другоеair-dried

Методика

To a hot solution of 2-thiophencarboxylic acid hydrazide (5.0 g, 35 mmol) in acetonitrile (80 mL) was added neat benzyl isothiocyanate (4.7 mL, 35 mmol) via syringe. When the solvent started to boil, the reaction vessel was removed from the heat source and allowed to cool to room temperature. The resulting crystals were collected by vacuum filtration, washed with diethyl ether and air-dried to yield N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide (9.11 g; 89%; (M+H)+−292.2).

Источник