Реакция #3164

Уравнение реакции

2-(aminoethoxy) ethanol

hexahydrophthalic anhydride

→

N-(2-hydroxyethoxyethyl)hexahydrophthalimide

Выход 96.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеA 500-ml, two necked flask was equipped with a magnetic stirring bar
2. 2
   Температураheating mantle and condenser
3. 3
   workup.ADDITIONAfter the addition
4. 4
   Температураwas refluxed for 12 hours
5. 5
   ДругоеThe ethanol was removed with a rotoevaporator

Методика

A 500-ml, two necked flask was equipped with a magnetic stirring bar, heating mantle and condenser. The flask was charged with 51 g of 2-(aminoethoxy) ethanol (0.49 mol.) and 250 ml of ethanol. Next, 75 g of hexahydrophthalic anhydride (0.49 mol.) was slowly added to the flask. After the addition was complete the reaction was refluxed for 12 hours. The IR spectrum indicated the reaction was complete. The ethanol was removed with a rotoevaporator to yield 113 g (96%) of N-(2-hydroxyethoxyethyl)hexahydrophthalimide.

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