Реакция #316039

Уравнение реакции

hydrochloric acid

Sodium hydroxide

water

5-Fluoro-1H-indole-2,3-dione

2-hydroxy-1-phenyl-ethanone

→

6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid

Выход 21.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеto prepare a solution
2. 2
   Промывкаthe precipitated crystal was washed with methanol and water

Методика

5-Fluoro-1H-indole-2,3-dione (1.19 g) and 2-hydroxy-1-phenyl-ethanone (2.25 g) were dissolved in methanol (70 ml) to prepare a solution. Sodium hydroxide (4.82 g) and water (30 ml) were added to the solution, and the mixture was stirred at room temperature overnight. Dilute hydrochloric acid was added to the reaction solution, and the precipitated crystal was washed with methanol and water to give 6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid (427 mg, yield 21%).

Источник