Реакция #314594

Уравнение реакции

methyl-indole-6-carboxylate

ethylmagnesium bromide

product

2,2,3,3-tetramethylcyclopropanecarbonyl chloride

→

title compound

Выход 40.0%

3-(2,2,3,3-Tetramethyl-cyclopropanecarbonyl)-1H-indole-6-carboxylic acid methyl ester

Выход 40.0%

Растворители

dichloromethane

Условия реакции

Методика

A mixture of methyl-indole-6-carboxylate (2.0 g, 11.4 mmol), ethylmagnesium bromide (1.0 M solution in THF, 14 mL, 14 mmol), zinc chloride (1.0 M solution in Et2O, 14 mL, 14 mmol) and the product of Example 1A (17 mmol) in 30 mL of dichloromethane was processed as described in Example 1B to provide the title compound (1.35 g, 4.5 mmol, 40% yield). MS (DCI/NH3) m/z 300 (M+H)+.

Источник