Реакция #313136

ord-9614183280bd4940b1805259a0fc8084

Уравнение реакции

CC(C)[C@@]1(C(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)O)CC(c2nccc3ccccc23)=NO1
(2S)-4-(tert-butoxy)-2-({[(5R)-5-isopropyl-3-(1-isoquinolinyl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)-4-oxobutanoic acid
C=[CH][Mg][Br]
vinyl magnesium bromide
→
C=CC(=O)[C@H](CC(=O)O)NC(=O)[C@]1(C(C)C)CC(c2nccc3ccccc23)=NO1
title compound
C=CC(=O)[C@H](CC(=O)O)NC(=O)[C@]1(C(C)C)CC(c2nccc3ccccc23)=NO1
(3S)-3-({[(5R)-5-isopropyl-3-(1-isoquinolinyl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)-4-oxo-5-hexenoic acid

Реактанты

—
Weinreb amide
CC(C)[C@@]1(C(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)O)CC(c2nccc3ccccc23)=NO1
(2S)-4-(tert-butoxy)-2-({[(5R)-5-isopropyl-3-(1-isoquinolinyl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)-4-oxobutanoic acid
C=[CH][Mg][Br]
vinyl magnesium bromide

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеthe resulting compound was reacted

Методика

Weinreb amide derivative of (2S)-4-(tert-butoxy)-2-({[(5R)-5-isopropyl-3-(1-isoquinolinyl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)-4-oxobutanoic acid (condensed derivative with N,O-dimethylhydroxylamine) and vinyl magnesium bromide were reacted, and the resulting compound was reacted according to the same procedure as Example 2 to give the title compound.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07557133B2uspto-grants-2009_07