Реакция #312361

Уравнение реакции

o-Hydroxybenzaldehyde

2-methyl-3-chloroaniline

→

N-(o-hydroxybenzylidene)-2-methyl-3-chloroaniline

Растворители

ethanol

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe reaction mixture was stirred vigorously for an additional 45 mins
2. 2
   workup.WAITThe reaction mixture was left
3. 3
   workup.WAITstanding at room temperature for 10 min.
4. 4
   workup.WAITit was placed in an ice-bath for 0.5 hour
5. 5
   ДругоеThe crystals which formed
6. 6
   Другоеwere collected
7. 7
   Промывкаwashed with 95% ethanol, and air
8. 8
   Другоеdried
9. 9
   ДругоеRecrystallization from 85% ethanol

Методика

o-Hydroxybenzaldehyde (0.20 mole) was treated with 2-methyl-3-chloroaniline (0.20 mole) with vigorous stirring in a 1 liter Erlenmeyer flask. After 15 mins., 33 cc of 95% ethanol was added and the reaction mixture was stirred vigorously for an additional 45 mins. The reaction mixture was left standing at room temperature for 10 min., then it was placed in an ice-bath for 0.5 hour. The crystals which formed were collected, washed with 95% ethanol, and air dried. Recrystallization from 85% ethanol gave N-(o-hydroxybenzylidene)-2-methyl-3-chloroaniline. m.p. 95°-97° C.

Источник