Реакция #311512

Уравнение реакции

3,4-Dimethoxyphenylacetic acid

thionyl chloride

→

3,4-dimethoxyphenylacetyl chloride

Растворители

benzene

Условия реакции

Обработка

1. 1
   Температураrefluxed for 2 hr
2. 2
   ДругоеThe solvent and SOCl2 were removed on a rotary evaporator
3. 3
   workup.ADDITIONTwo additional quantities of dry benzene were added to the residue
4. 4
   Другоеfollowed by rotary evaporation which

Методика

3,4-Dimethoxyphenylacetic acid (6.47 g, 0.033 mole) was dissolved in 50 ml of dry benzene and refluxed for 2 hr. with excess thionyl chloride (25 ml). The solvent and SOCl2 were removed on a rotary evaporator. Two additional quantities of dry benzene were added to the residue, followed by rotary evaporation which yielded 3,4-dimethoxyphenylacetyl chloride.

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