Реакция #310602

Уравнение реакции

2-Bromopropionyl chloride

benzyl alcohol

water

→

benzyl 2-bromopropionate

Растворители

diethyl ether

Условия реакции

Обработка

1. 1
   Другоеthe temperature of the reaction mixture below 30° C.
2. 2
   workup.STIRRINGthe mixture was stirred for another two hours at ambient temperature
3. 3
   Промывкаwashed with water until free of acid
4. 4
   ДругоеThe ethereal solution was dried
5. 5
   Другоеevaporated
6. 6
   workup.DISTILLATIONthe residue distilled

Методика

2-Bromopropionyl chloride (213.4 g) was added dropwise to benzyl alcohol (145.8 g) with stirring under a stream of nitrogen, keeping the temperature of the reaction mixture below 30° C. by cooling with cold water. When all the acid chloride has been added, the mixture was stirred for another two hours at ambient temperature. The reaction mixture was then diluted with diethyl ether (200 ml) and washed with water until free of acid. The ethereal solution was dried and evaporated and the residue distilled to give benzyl 2-bromopropionate, b.p. 82°-85°/0.5 Torr.

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