Реакция #310431

Уравнение реакции

stearylamine

benzoyl chloride

hydrogen chloride

→

crystals

Выход 83.0%

N-stearylbenzamide

Выход 83.0%

Растворители

toluene

Условия реакции

Обработка

1. 1
   ДругоеAn exothermic reaction
2. 2
   ТемператураThe reaction mixture was heated to 100° C.
3. 3
   Другоеwas terminated
4. 4
   ТемператураThe reaction mixture was cooled, from which white crude crystals
5. 5
   Другоеwere separated
6. 6
   Другоеwere then recrystallized from alcohol
7. 7
   ДругоеThis recrystallization

Методика

27 g of stearylamine was dispersed in 100 ml of toluene. To this dispersion was added 13 g of benzoyl chloride at 70° C. An exothermic reaction occurred and the temperature of the mixture increased to 80° C. The reaction mixture was heated to 100° C. and that temperature was maintained for about 20 hours until generation of hydrogen chloride gas was terminated. The reaction mixture was cooled, from which white crude crystals were separated. The thus obtained white crystals were neutralized with sodium hydroxide and were then recrystallized from alcohol. This recrystallization gave white crystals melting at 85° C. to 87° C. The yield was 83%.

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