Реакция #310301

Уравнение реакции

Indanone

→

indanol

Выход 74.4%

Растворители

benzene

ether

Условия реакции

Обработка

1. 1
   workup.ADDITIONpoured out into ice
2. 2
   Экстракцияextracted with ether
3. 3
   ПромывкаThe solution in ether is washed with NaCl solution
4. 4
   Другоеdried
5. 5
   Другоеevaporated
6. 6
   workup.DISTILLATIONThe residue is distilled under diminished pressure

Методика

20 g Indanone (obtained according to Example VIII) is added to a solution of 1.5 molequivalent NaAlH2 (OC2H4OCH3)2 in a mixture of benzene and ether in the course of which the temperature raises to 35° C. Then the reaction mixture is stirred during one hour, poured out into ice and extracted with ether. The solution in ether is washed with NaCl solution, dried and evaporated. The residue is distilled under diminished pressure yielding 15.1 g indanol. B.p. 115° C./1 mm Hg. The indanol is dissolved in 100 ml cyclohexane and during 30 min. gaseous HCl is introduced followed by N2 to remove the excess of HCl. The reaction mixture is evaporated and the residue is distilled under diminished pressure yielding 12.9 g indanyl chloride. B.p. 95° C./1 mm Hg.

Источник