Реакция #308659

Уравнение реакции

3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

N-bromosuccinimide

→

1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

Выход 57.8%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеIn a 100 mL dried flask
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for an hour until the reaction
3. 3
   КонцентрированиеThe reaction mixture was concentrated under reduced pressure
4. 4
   ДругоеThe resulting residue was purified by silica gel column chromatography

Методика

In a 100 mL dried flask, the compound obtained from the previous step, 3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester 27a (300 mg, 1.04 mmol) was dissolved in 50 mL of ethanol under stirring, and N-bromosuccinimide (369 mg, 2.08 mmol) was then added to the solution. The reaction mixture was stirred at room temperature for an hour until the reaction was complete. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound 1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester 27b (220 mg, yield 57.8%) as a white solid.

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