Реакция #307666

Уравнение реакции

potassium carbonate

1H-pyrazole-4-carboxaldehyde

DCM

cyclopropylbromide

→

1-Cyclopropyl-1H-pyrazole-4-carbaldehyde

Растворители

N,N-dimethylformamide

water

Условия реакции

Обработка

1. 1
   ТемператураCool to ambient temperature
2. 2
   ЭкстракцияSeparate layers and extract water layer 3 times with DCM
3. 3
   ПромывкаWash
4. 4
   Сушкаdry (magnesium sulfate)
5. 5
   Фильтрацияfilter
6. 6
   Концентрированиеconcentrated
7. 7
   Другоеto give the free base of the title
8. 8
   Другоеpreparation

Методика

Dissolve 1H-pyrazole-4-carboxaldehyde in N,N-dimethylformamide (1.9 mL). Add potassium carbonate (0.539 g, 3.90 mmol) and cyclopropylbromide (0.346 g, 2.86 mmol). Heat in a pressure tube to 130° C. for 18 hr. Cool to ambient temperature and add DCM and water. Separate layers and extract water layer 3 times with DCM. Wash combined DCM layers with brine, dry (magnesium sulfate), filter, and concentrated to give the free base of the title preparation. GC-MS: m/z=136 [M+].

Источник