Реакция #3049

Уравнение реакции

Water

Allyl bromide

2-t-butylphenol

potassium carbonate

→

2-(1,1-dimethylethyl)phenoxypropene

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураat reflux temperature for 50 hours
2. 2
   Другоеthe resulting layers were separated
3. 3
   ЭкстракцияThe aqueous layer was extracted with 600 ml of diethyl ether
4. 4
   Экстракцияextract
5. 5
   Сушкаthe resulting solution was dried over sodium sulfate overnight
6. 6
   ДругоеAfter sodium sulfate removal
7. 7
   Другоеthe solvent was evaporated
8. 8
   Другоеto provide

Методика

Allyl bromide (69.2 ml), 2-t-butylphenol (122.9 ml) and potassium carbonate (121.6 g) were stirred in 265 ml of acetone at reflux temperature for 50 hours and then cooled to 35° C. Water (600 ml) was added and the resulting layers were separated. The aqueous layer was extracted with 600 ml of diethyl ether. The organic layer was combined with the aqueous layer's ether extract and the resulting solution was dried over sodium sulfate overnight. After sodium sulfate removal, the solvent was evaporated to provide, after further workup, 147 g of the subtitled intermediate.

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