Реакция #302976

Уравнение реакции

methanol

5-chloroisatoic anhydride

NaH

5-fluoroisatin

→

2-Chloro-8-fluoroindolo[2,1-b]quinazoline-6,12-dione

Растворители

chloroform

DMF

DMF

DMF

Условия реакции

Обработка

1. 1
   Промывкаthe organic solution was washed with water
2. 2
   Сушкаdried (MgSO4)
3. 3
   Концентрированиеconcentrated
4. 4
   Другоеto give a residue that
5. 5
   Другоеwas purified by silica gel chromatography (CHCl3:CH3OH)

Методика

To a suspension of NaH (10 mmol, 40 mg 60%) in 4 mL of DMF was added 10 mmol of 5-fluoroisatin in 2 mL of DMF. After 15 min, a solution of 5-chloroisatoic anhydride in 3 mL of DMF was added. The reaction mixture was stirred for 18 h, methanol (0.5 mL) and 20 mL of chloroform was added and the organic solution was washed with water, dried (MgSO4) and concentrated to give a residue that was purified by silica gel chromatography (CHCl3:CH3OH). Yield 77%: mp 280-282° C.

Источник