Реакция #302892

Уравнение реакции

2,3-dimethylbenzylamine

2-chloroethylisothiocyanate

→

title compound

Выход 76.0%

((2,3-dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Выход 76.0%

Растворители

1,4-dioxane

Условия реакции

Обработка

1. 1
   Температураto cool
2. 2
   Другоеa solid precipitate that had formed
3. 3
   Фильтрацияwas collected by filtration
4. 4
   ПромывкаThe solid was rinsed with diethyl ether
5. 5
   Другоеwas dried under reduced pressure

Методика

Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of 2,3-dimethylbenzylamine and 5.0 grams (0.041 mole) of 2-chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

Источник