Реакция #302890

Уравнение реакции

2,3-dichlorobenzylamine

2-chloroethylisothiocyanate

→

title compound

Выход 163.2%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Выход 163.2%

Растворители

1,4-dioxane

Условия реакции

Обработка

1. 1
   Другоеwas placed in a sealed reaction vial
2. 2
   Температураto cool
3. 3
   Другоеa solid precipitate that had formed
4. 4
   Фильтрацияwas collected by filtration
5. 5
   ПромывкаThe solid was rinsed with diethyl ether
6. 6
   Другоеwas dried under reduced pressure

Методика

A mixture of 0.5 gram (0.0028 mole) of 2,3-dichlorobenzylamine and 0.27 gram (0.0081 mole) of 2-chloroethylisothiocyanate in 10 mL of 1,4-dioxane was placed in a sealed reaction vial. The reaction mixture was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 0.68 gram of the title compound. The NMR spectrum was consistent with the proposed structure.

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