Реакция #302866

Уравнение реакции

t-butylphenol

aniline

→

t-BuPh

Условия реакции

Обработка

1. 1
   workup.ADDITIONmixed in an oil bath at 90° C
2. 2
   Другоеafter about 30 minutes
3. 3
   Другоеthe reaction was quenched
4. 4
   ТемператураThe cooled crude product
5. 5
   Промывкаwas base-washed twice through a solvent extraction
6. 6
   Промывкаwashed once with deionized water
7. 7
   ПромывкаAfter washing
8. 8
   Сушкаthe organic layer was dried with MgSO4
9. 9
   Фильтрацияfiltered
10. 10
    ДругоеThe residual solution was dried
11. 11
    Другоеa rotary evaporator
12. 12
    Другоеto remove the solvent
13. 13
    Другоеthe purified product was dried in a vacuum oven at 40° C. for 6 hours

Методика

15 g (0.1 mol) of t-butylphenol, 6.31 g (0.21 mol) of p-formaldehyde and 10.24 g (0.11 mol) of aniline were added to a 100 ml one-neck round-bottom flask and mixed in an oil bath at 90° C. When the initially opaque mixture became a dark brown transparent gel type material after about 30 minutes, the reaction was quenched using tetrahydrofuran (THF), and then the mixture was cooled to room temperature. The cooled crude product was base-washed twice through a solvent extraction using a 1N NaOH aqueous solution, and washed once with deionized water. After washing, the organic layer was dried with MgSO4 and filtered. The residual solution was dried using a rotary evaporator to remove the solvent, and the purified product was dried in a vacuum oven at 40° C. for 6 hours to obtain t-BuPh-a.

Источник