Реакция #302858

Уравнение реакции

compound 22

1-(5-methoxy-2-hydroxyphenyl)-3-(4-nitrophenyl)propan-1,3-dione

sulfuric acid

→

6-methoxy-4′-nitroflavone

compound 23

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураto reflux for 1 hour
3. 3
   Другоеwas returned to room temperature
4. 4
   workup.ADDITIONice pieces were then added to the reaction solution
5. 5
   ФильтрацияThe precipitated crystal was collected by filtration

Методика

A mixed solution consisting of compound 22 (2.92 g, 9.26 mmol), concentrated sulfuric acid (1 ml), and acetic acid (50 ml) was heated to reflux for 1 hour. The temperature of the resultant was returned to room temperature, and ice pieces were then added to the reaction solution. The precipitated crystal was collected by filtration, so as to obtain a product of interest, 6-methoxy-4′-nitroflavone (compound 23). Yield: 2.31 g (yield constant: 84.1%)

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