Реакция #302847

Уравнение реакции

compound 3

1-(5-bromo-2-hydroxyphenyl)-3-(4-nitrophenyl)propan-1,3-dione

sulfuric acid

→

compound 4

6-bromo-4′-nitroflavone

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураto reflux for 1 hour
3. 3
   Другоеwas returned to room temperature
4. 4
   workup.ADDITIONice pieces were then added to the reaction solution
5. 5
   ФильтрацияThe precipitated crystal was collected by filtration

Методика

A mixed solution consisting of compound 3 (2.00 g, 5.49 mmol), concentrated sulfuric acid (0.5 ml), and acetic acid (40 ml) was heated to reflux for 1 hour. The temperature of the resultant was returned to room temperature, and ice pieces were then added to the reaction solution. The precipitated crystal was collected by filtration, so as to obtain a product of interest, 6-bromo-4′-nitroflavone (compound 4). Yield: 1.79 g (yield constant: 94.2%) MS m/z 347 (MH+).

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