Реакция #3020

Уравнение реакции

BOP

triethylamine

1-(methoxycarbonylmethyl)-2-indolecarboxylic acid

[(2,6-dimethoxy-4-methylphenyl)(isopentyl)carbamoyl]methylamine hydrochloride

compound 100

[(2,6-dimethoxy-4-methylphenyl)(isopentyl)carbamoyl]methylamine hydrochloride

water

→

methyl{2-[[(2,6-dimethoxy-4-methylphenyl)(isopentyl)carbamoyl]methylcarbamoyl]-1-indolyl}acetate

Выход 91.0%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Экстракцияthe aqueous phase is extracted with ethyl acetate
2. 2
   ПромывкаThe organic extracts are washed with water
3. 3
   Сушкаdried over anhydrous sodium sulphate
4. 4
   ДругоеEvaporation of the solvent
5. 5
   Другоеleaves a yellow oil which
6. 6
   Другоеis purified by flash chromatography on a column of silica gel, eluent

Методика

0.8 9 of [(2,6-dimethoxy-4-methylphenyl)(isopentyl)carbamoyl]methylamine hydrochloride (compound 100) is dissolved in 10 ml of dimethylformamide and 0.58 g of 1-(methoxycarbonylmethyl)-2-indolecarboxylic acid, 1.12 g of BOP and then, dropwise, 0.75 g of triethylamine are successively added to the reaction mixture at room temperature. The reaction mixture is left at room temperature for 20 hours, is then poured into cold water and the aqueous phase is extracted with ethyl acetate. The organic extracts are washed with water and then dried over anhydrous sodium sulphate. Evaporation of the solvent leaves a yellow oil which is purified by flash chromatography on a column of silica gel, eluent: dichloromethane/methanol 98/2 (v/v) in order to obtain white crystals of methyl{2-[[(2,6-dimethoxy-4-methylphenyl)(isopentyl)carbamoyl]methylcarbamoyl]-1-indolyl}acetate; M.p.=141° C.; Yield: 91%.

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