Реакция #3018

Уравнение реакции

water

isovaleryl chloride

2,6-dimethoxy-4-methylaniline

triethylamine

→

N-(2,6-dimethoxy-4-methylphenyl)isovaleramide

Выход 92.0%

Растворители

diethyl ether

Условия реакции

Обработка

1. 1
   workup.ADDITIONare added to the reaction mixture
2. 2
   ЭкстракцияThe aqueous phase is extracted with ethyl acetate
3. 3
   Другоеafter separation
4. 4
   Промывкаwashed with water
5. 5
   Сушкаdried over anhydrous sodium sulphate
6. 6
   Другоеevaporated to dryness

Методика

8.2 g of 2,6-dimethoxy-4-methylaniline are dissolved in 100 ml of diethyl ether at 0° C. under an inert atmosphere, 5.96 g of triethylamine are added to the reaction mixture and then 6.51 g of isovaleryl chloride are added dropwise, while maintaining the temperature at 0° C. The mixture is left at room temperature for 30 minutes and is then poured into 250 ml of water. The aqueous phase is extracted with ethyl acetate after separation by settling of the ethereal phase. The organic phases are combined and washed with water, then dried over anhydrous sodium sulphate and evaporated to dryness. The white crystals of N-(2,6-dimethoxy-4-methylphenyl)isovaleramide obtained are washed with diisopropyl ether; M.p.=139° C., Yield: 92%.

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