Реакция #2974

Уравнение реакции

(±)-trans-6-ethyl-8a-(3-methoxyphenyl)-3-methyl-2-pyrrolidinocarbonyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline

boron tribromide

→

title compound

Выход 23.3%

(±)-trans-6-Ethyl-8a-(3-hydroxyphenyl)-3-methyl-2-pyrrolidinocarbonyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline

Выход 23.3%

Условия реакции

Обработка

1. 1
   ДругоеThe residue was purified by flash chromatography (EtOAc/MeOH/conc. NH4OH 80:20:0.5)
2. 2
   ДругоеThe resulting solid was triturated with Et2O

Методика

0.63 g (1.37 mmol) of (±)-trans-6-ethyl-8a-(3-methoxyphenyl)-3-methyl-2-pyrrolidinocarbonyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline were treated with 0.77 ml (8.22 mmol) of boron tribromide as described in example 2. The residue was purified by flash chromatography (EtOAc/MeOH/conc. NH4OH 80:20:0.5). The resulting solid was triturated with Et2O, yielding 0.13 g of the title compound. M.p.=224°-226° C.

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