Реакция #2945

Уравнение реакции

diketene acetone

pyrrolidine

→

title compound

Выход 97.9%

1-(3-Oxobutyryl)pyrrolidine

Выход 97.9%

Растворители

toluene

Условия реакции

Обработка

1. 1
   Другоеas described in preparation 7
2. 2
   ДругоеThe solvent was removed in vacuo
3. 3
   Другоеthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

Методика

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

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