Реакция #2898

Уравнение реакции

iodomethane

4-Bromo-3,5-dimethylpyrazole

sodium hydride

sodium hydrogen carbonate

hydrogen

→

title compound

4-Bromo-1,3,5-trimethylpyrazole

Растворители

dimethylformamide

dimethylformamide

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Другоеevaporation under high vacuum
3. 3
   Другоеthe residue was purified by column chromatography

Методика

4-Bromo-3,5-dimethylpyrazole (10 g) in dry dimethylformamide (50 ml) was added to a stirred suspension of sodium hydride (1.8 g) in dry dimethylformamide at 0° C. When the evolution of hydrogen was complete, iodomethane (8.9 g) was added dropwise. The mixture was allowed to warm to room temperature and after 30 minutes saturated aqueous sodium hydrogen carbonate (5 ml) was added. Following evaporation under high vacuum, the residue was purified by column chromatography to give the title compound.

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