Реакция #2876

Уравнение реакции

N-bromosuccinimide

5-bromo-2-fluoro-benzyl alcohol

triphenyl phosphine

→

title compound

Выход 96.7%

5-Bromo-2-fluoro-benzyl bromide

Выход 96.7%

Растворители

THF

Условия реакции

Обработка

1. 1
   ДругоеThe ice bath is removed
2. 2
   ДругоеThe crude product is purified by column chromatography
3. 3
   Промывкаeluting with 5% EtOAc/hexanes

Методика

To a solution of 5-bromo-2-fluoro-benzyl alcohol (3.10 g, 15.1 mmol) in 30 mL of THF at 10° C. is added triphenyl phosphine (4.10 g, 15.6 mmol) followed by N-bromosuccinimide (2.67 g, 15.0 mmol). The ice bath is removed and the resulting solution is stirred for 20 min at room temperature. The crude product is purified by column chromatography eluting with 5% EtOAc/hexanes to give the title compound (3.90 g, 14.5 mmol).

Источник