Реакция #2855

Уравнение реакции

3-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-hydroxy-benzonitrile hydrochloride

4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride

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title compound

4,6-Dichlorobenzo[b]thiophene-2-sulfonic acid [1-(2-hydroxy-5-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-amide

Растворители

pyridine

Условия реакции

Обработка

1. 1
   Температураto warm to ambient temperatures
2. 2
   КонцентрированиеAfter this time, the solution is concentrated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in CH2 Cl2
4. 4
   ПромывкаThe organic solution is washed with 1N HCl and saturated NaCl
5. 5
   ДругоеThe crude product is triturated with Et2O

Методика

To a solution of 3-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-hydroxy-benzonitrile hydrochloride (0.20 g, 0.75 mmol) in 3 mL of pyridine at 0° C. is added 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The solution is allowed to warm to ambient temperatures and is stirred for 6 h. After this time, the solution is concentrated. The residue is dissolved in CH2 Cl2. The organic solution is washed with 1N HCl and saturated NaCl. The crude product is triturated with Et2O to give the title compound (0.22 g, 0.44 mmol) as a white solid.

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