Реакция #2829

Уравнение реакции

compound ( [5]-(54)-75 )

4-hexyl-3-nitrobenzoic acid morpholide

hydrazine monohydrate

→

compound ( [5]-(55)-75 )

Выход 99.4%

3-amino-4-hexylbenzoic acid morpholide

Выход 99.4%

Растворители

ethanol

ethanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Фильтрацияthe solution was filtered through celite 545
3. 3
   Другоеto remove the catalyst
4. 4
   ДругоеThe solvent was evaporated under reduced pressure
5. 5
   ДругоеThe residue was purified by silica gel column chromatography (Kieselgel 60=20 g, ethyl acetate)

Методика

The compound ([5]-(54)-75) (700 mg) prepared in Example 62 was dissolved in ethanol (35 ml). After the solution was heated to 50° C., a suspension of 10% Pd/C (70 mg) in ethanol was added, and hydrazine monohydrate (0.35 ml) was added to the solution. The solution was stirred at 50° C. for 30 minutes. After the reaction was completed, the solution was filtered through celite 545 to remove the catalyst. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (Kieselgel 60=20 g, ethyl acetate) to obtain the above-captioned compound ([5]-(55)-75) (631 mg) as colorless oil.

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