Реакция #2799

Уравнение реакции

chloroacetyl chloride

N-methylmorpholine

morpholine

→

chloroacetic acid morpholine carboxamide

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ТемператураCool in an ice-bath
2. 2
   ЭкстракцияExtract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
3. 3
   СушкаDry the organic layer over Na2SO4
4. 4
   Фильтрацияfilter
5. 5
   Другоеevaporate in vacuo

Методика

Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to obtain chloroacetic acid morpholine carboxamide.

Источник