Реакция #2777

ord-989c68d91dfc4d74a9b62cfdff0165f9

Уравнение реакции

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O
biotin-N-hydroxysuccinimide
NCCc1ccc(O)cc1
tyramine
CC[NH+](CC)CC.O=C([O-])O
triethylammonium bicarbonate
→
NCCc1ccc(O)cc1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21
biotin tyramine

Реактанты

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O
biotin-N-hydroxysuccinimide
NCCc1ccc(O)cc1
tyramine
CC[NH+](CC)CC.O=C([O-])O
triethylammonium bicarbonate

Реагенты

Нет

Растворители

CN(C)C=O
dimethylformamide

Условия реакции

Температура
50°CELSIUS
Подробные условия
See reaction.notes.procedure_details.

Методика

a solution of biotin-N-hydroxysuccinimide, 170 mg (0.5 mMoles), and tyramine (recrystallized from water), 68.5 mg (0.5 mMoles), in 25 ml dimethylformamide was treated with 10 ml of 1M triethylammonium bicarbonate, pH 7.5, and then heated at 50° C. for 3 hours.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US05731158uspto-grants-1998_03