Реакция #2736

Уравнение реакции

benzoate

ethanol

hydrochloric acid

potassium hydroxide

→

desired product

Выход 89.3%

4-(2,4-nonadiynyloxy)benzoic acid

Выход 89.3%

Растворители

water

water

Условия реакции

Обработка

1. 1
   ДругоеIn a flask were placed
2. 2
   workup.ADDITIONwas added to the mixture
3. 3
   Температураcooled
4. 4
   Другоеformed
5. 5
   ФильтрацияThe crystals were recovered by filtration
6. 6
   Промывкаwashed with water
7. 7
   Другоеdried

Методика

In a flask were placed 4.0 g (0.014 mole) of the benzoate derivative obtained and 18 ml of ethanol and while stirring the mixture at room temperature, an aqueous solution composed of 2.0 g (0.36 mole) of potassium hydroxide and 20 ml of water was added to the mixture. After stirring the mixture for 24 hours at 40° C. Twenty (20) ml of water was added to the mixture followed by ice-cooled. When the reaction mixture was acidified with concentrated hydrochloric acid, white crystals formed. The crystals were recovered by filtration, washed with water, and dried. Thus, 3.2 g (yield 89.3%) of the desired product could be obtained. The melting point was 165°-166° C.

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