Реакция #2603

ord-04858e3c86474c34819e6545cb9b7d88

Уравнение реакции

COc1ccccc1N(CCN1CCC(C(=O)c2ccc(F)cc2)CC1)C(=O)c1ccc(CN)cc1
4-aminomethyl-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide
CCOC(=O)Cl
ethyl chloroformate
CCOC(=O)NCc1ccc(C(=O)N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc2OC)cc1
title compound
Выход 72.7%
CCOC(=O)NCc1ccc(C(=O)N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc2OC)cc1
4-(Ethoxycarbonylamino)methyl-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide
Выход 72.7%

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Using 4-aminomethyl-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide (60 mg, 0.123 mmol) and ethyl chloroformate (13 μl, 0.136 mmol), the procedure of Inventive Example 94 was repeated to obtain 50 mg (72.7%) of the title compound in a colorless amorphous form.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US05728835uspto-grants-1998_03