Реакция #2568

Уравнение реакции

water

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-formyl-N-(2-methoxyphenyl)benzenesulfonamide

hydroxyamine hydrochloride

sodium carbonate

→

title compound

Выход 102.7%

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-(N-hydroxyimino)-N-(2-methoxyphenyl)benzenesulfonamide

Выход 102.7%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Другоеethanol was removed by evaporation
2. 2
   workup.ADDITIONthe resulting residue was mixed with water (10 ml)
3. 3
   Другоеto collect crystals
4. 4
   Фильтрацияby filtration
5. 5
   ПромывкаThe thus collected crystals were washed with water and hexane
6. 6
   workup.DISSOLUTIONdissolved in methylene chloride (50 ml)
7. 7
   Сушкаdried on anhydrous sodium carbonate
8. 8
   ДругоеThereafter, the solvent was removed by evaporation

Методика

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-formyl-N-(2-methoxyphenyl)benzenesulfonamide (63 mg, 0.12 mmol) and hydroxyamine hydrochloride (9.5 mg, 0.132 mmol) were dissolved in ethanol (2 ml) to which were subsequently added anhydrous sodium carbonate (14 mg, 0.132 mmol) and water (1 ml). After 1.5 hours of stirring at room temperature, ethanol was removed by evaporation, and the resulting residue was mixed with water (10 ml) to collect crystals by filtration. The thus collected crystals were washed with water and hexane, dissolved in methylene chloride (50 ml) and then dried on anhydrous sodium carbonate. Thereafter, the solvent was removed by evaporation to obtain 65 mg (100%) of the title compound in the form of colorless powder.

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