Реакция #2560

Уравнение реакции

N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide

triethylamine

→

title compound

Выход 65.6%

N-Formylmethyl-3-methoxy-N-(2-methoxyphenyl)benzamide

Выход 65.6%

Растворители

DMSO

DMSO

Условия реакции

Обработка

1. 1
   Другоеat room temperature
2. 2
   Экстракцияextracted with ethyl acetate
3. 3
   Промывкаwashed with water and saturated brine
4. 4
   СушкаThe resulting organic layer was dried on anhydrous magnesium sulfate
5. 5
   Другоеthe solvent was removed by evaporation

Методика

In an atmosphere of argon, N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide (339 mg, 1.12 mmol) was dissolved in DMSO (4 ml) to which were subsequently added dropwise triethylamine (0.724 ml, 5.20 mmol) and a DMSO solution (8 ml) of a sulfur trioxide-pyridine complex (844 mg, 5.20 mmol) at room temperature. After 20 minutes of stirring at the same temperature, this was mixed with ice water (40 ml) and extracted with ethyl acetate, and then washed with water and saturated brine. The resulting organic layer was dried on anhydrous magnesium sulfate, and the solvent was removed by evaporation to obtain 220 mg (65.6%) of the title compound the form of light yellow solid.

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