Реакция #2556

Уравнение реакции

4-(4-Fluorobenzoyl)piperidine

bromoacetoaldehyde diethylacetal

triethylamine

→

title compound

Выход 25.0%

1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine

Выход 25.0%

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   ТемператураAfter 12 hours of heating
2. 2
   Температураunder reflux
3. 3
   Другоеthe solvent was removed by evaporation
4. 4
   Другоеthe resulting residue was purified

Методика

4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.

Источник