Реакция #2551

Уравнение реакции

4-Chloromethyl-N-(2-methoxyphenyl)benzamide

methylamine

→

title compound

Выход 100.0%

N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

Выход 100.0%

Растворители

dioxane

dioxane

Условия реакции

Обработка

1. 1
   Другоеwas removed by evaporation
2. 2
   workup.ADDITIONthe resulting residue was diluted with methylene chloride (10 ml)
3. 3
   СушкаAfter drying on anhydrous sodium carbonate
4. 4
   Другоеthe solvent was removed by evaporation

Методика

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

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