Реакция #2511218

Уравнение реакции

pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone

→

title compound

Выход 17.1%

6-{2-{{4-[2-(7-Azabicyclo[2.2.1]hept-7-yl)ethoxy]benzyl}ethylamino}-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

Выход 17.1%

Условия реакции

Обработка

1. 1
   Другоеpurified by LC-MS

Методика

Synthesized from pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone (15 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (1.7 mg) was obtained.

Источник