Реакция #2502813

ord-c60b91e4277b478cb62af7f64a48aac4

Уравнение реакции

CC(=O)Nc1ccc(O)cc1
acetaminophen
CC(=O)Oc1ccccc1C(=O)O
aspirin
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
→
CC(=O)Nc1ccc(O)cc1.CC(=O)Oc1ccccc1C(=O)O
Acetaminophen Aspirin

Реактанты

CC(=O)Nc1ccc(O)cc1
acetaminophen
CC(=O)Oc1ccccc1C(=O)O
aspirin
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
—
cellulose
—
cellulose

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеa dwell time of 1 min

Методика

320 mg of acetaminophen or aspirin (USP Powder, CAS-50-78-2), 175 mg of microfibrillated/powdered cellulose or microcrystalline cellulose (Avicel PH-102), and 5 mg of magnesium stearate were homogenously mixed and then compressed on a Carver Press using a 10-mm die and punches and a pressure of 4000 lbs and a dwell time of 1 min. The hardness and disintegration times of tablets are presented in Table 3.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06821531B2uspto-grants-2004_11