Реакция #2487410

Уравнение реакции

lipoic acid

N-hydroxysuccinimide

EDC

→

(R)-Lipoamide

Растворители

CH2Cl2

ethyl acetate

Условия реакции

Обработка

1. 1
   Промывкаwashed with H2O (500 mL), saturated aqueous NaHCO3 (500 mL), saturated aqueous NaCl (500 mL)
2. 2
   Сушкаdried (MgSO4)
3. 3
   ДругоеThe drying agent was removed by filtration
4. 4
   Концентрированиеthe filtrate was concentrated to dryness
5. 5
   Другоеgiving the product as

Методика

A solution of lipoic acid (25.6 g, 124 mmol), N-hydroxysuccinimide (15.6 g, 136 mmol), and EDC (26.1 g, 136 mmol) in anhydrous CH2Cl2 (300 mL) was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate (500 mL) and washed with H2O (500 mL), saturated aqueous NaHCO3 (500 mL), saturated aqueous NaCl (500 mL) and dried (MgSO4). The drying agent was removed by filtration and the filtrate was concentrated to dryness giving the product as a yellow sold (35.4 g, 94%).

Источник