Реакция #2467985

Уравнение реакции

Methyl 4-aminothiophene-3-carboxylate hydrochloride

ammonia

→

oil

Выход 65.0%

Methyl 4-aminothiophene-3-carboxylate

Выход 65.0%

Растворители

water

Условия реакции

Обработка

1. 1
   ЭкстракцияThe solution was extracted with chloroform
2. 2
   Промывкаthe combined chloroform layer was washed with water, brine
3. 3
   Сушкаdried over sodium sulfate
4. 4
   ФильтрацияThe solution was filtered
5. 5
   Другоеevaporated the solvent

Методика

Methyl 4-aminothiophene-3-carboxylate hydrochloride (290 mg) was dissolved in water (20 mL) and basified with ammonia solution. The solution was extracted with chloroform and the combined chloroform layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the product as pale yellow color oil (150 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.92 (1H, d, J=3.6 Hz), 6.08 (1H, d, J=3.6 Hz), 4.79 (2H, br s), 3.85 (3H, s).

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